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[2] mhra.gov.uk)
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Repeatedly applying patches to the same location can cause contact dermatitis, skin sensitization, or localized tissue changes that impair drug absorption
The cellular mechanism by which the releasing hormones affect GH secretion from the somatotrope requires specific signal transduction systems (cAMP and/or calcium influx and/or mobilization of intracellular calcium) and/ or tyrosine kinase(s) and/or nitric oxide (NO)/cGMP
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