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Inicialmente, se comercializaron monoagonistas de GLP-1R que tuvieron como objetivo el tratamiento de la diabetes tipo2, explotando el efecto incretnico y su carcter glucosa-dependiente, a lo que se aadi la accin reductora del peso corporal y sus efectos sobre comorbilidades asociadas1,3,5
These actions support a more stable postprandial (after-meal) blood glucose profile
Tirzepatide (marketed in September 2022) was excluded due to insufficient data, and semaglutide was the latest drug of interest to be marketed (December 2017)
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