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More recently, encouraging clinical results from a triple-hormone-receptor agonist, Retatrutide, and several GLP-1R/GCGR dual agonists, suggest that GCGR could be a promising co-stimulating target for type 2 diabetes and obesity.
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Tirzepatide contributed 48,649 more life-years gained per 100,000 people, and semaglutide generated 35,634 more life-years gained per 100,000 people than lifestyle intervention alone
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