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After analyzing the effect of NR on the physiopathology and cellular mechanisms in the 3xTgAD/Pol mouse model (mice deficient in DNA repair that exacerbates the main characteristics of AD in humans) it was observed that supplementation with NR significantly increased the NAD + /NADH ratio, reduced neuroinflammation, apoptosis and damage to DNA, increased neurogenesis, restored synaptic plasticity, improved learning capacity and reversed memory deficits (Hou et al., 2017a)
However, the effectiveness of oral glutathione remains controversial due to its breakdown by stomach enzymes
Yang et al., 2023)
Carnitine, carnitine acyltransferases, and rat brain function
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