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For inflammatory bowel disease, mesalamine, corticosteroids, immunomodulators (azathioprine, methotrexate), and biologics (infliximab, adalimumab, vedolizumab, ustekinumab) all have Level 1 evidence from Phase III trials with thousands of patients

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Specifically, mycotoxins have been shown to: Suppress cytokine production, altering immune signaling Induce apoptosis (programmed cell death) in immune cells Disrupt the intestinal epithelial barrier, contributing to leaky gut Impair macrophage and dendritic cell function Alter the balance between inflammatory and regulatory immune pathways (Th1/Th2/Th17/Treg axis) Aspergillus fumigatus produces gliotoxin, which actively suppresses the immune systems ability to fight off fungal infection by inhibiting phagocytosis