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The most common baseline comorbidities were hypertension (94.6%) and hypercholesterolemia (88.9%), and common cardiovascular comorbidities included coronary heart disease (43.8%) and congestive heart failure (CHF
Given the central role of diastolic dysfunction and fibrosis in the pathophysiology of HFpEF, these improvements likely contribute to the clinical benefits seen in patients treated with SEMA
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