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ABSTRACT Obesity and its related metabolic comorbidities, including type 2 diabetes, metabolic dysfunction-associated steatotic liver disease, and cardiovascular disease, are increasingly recognized as heterogeneous and multisystemic disorders

More specifically, fibrosis has been linked to a decrease in overall microbial diversity and an increase in gram-negative bacteria, which has been postulated to be a source of inflammatory endotoxin [143]

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