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Unlike GHRH analogues (such as Sermorelin or CJC-1295) which act at the GHRH receptor via cyclic AMP-dependent signalling, Ipamorelin triggers rapid GH release through GHS-Rmediated pathways at the hypothalamus and anterior pituitary
This nonselectivity underlies the potential for extracutaneous actions (e.g., overlapping with other melanocortin pathways), though MC1Rs high affinity and strong signaling efficacy make it the principal molecular target in skin and immune contexts
17% with placebo, though fibrosis stage did not significantly improve
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