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Individuals most likely to benefit include: Those with pernicious anemia People with gastrointestinal disorders (e.g., Crohns disease, celiac disease, chronic gastritis) Patients following bariatric (weight loss) surgery Older adults with absorption difficulties Strict vegetarians or vegans at risk for deficiency People taking medications that can decrease vitamin B12 levels Laboratory testing usually confirms B12 deficiency before starting injections
Overall, task-based paradigms rely on controlled, repeatable trials to extract high signal-to-noise indices targeting specific motor or cognitive pathways, whereas real-world paradigms prioritize ecological validity and phenotypic diversity, better reflecting the real-world functional status
Sims et al., 2013
