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The dynamic changes in the carnitine pool under physiological and pathological conditions are extremely complex, and existing research may not yet have fully revealed the complete picture
Yet the consequences are unknown Bioavailability: there are four specific metabolic steps necessary to convert cyanocobalamin into one of the coenzyme forms, which is a clear metabolic disadvantage (3) Utilisation problems: certain hereditary diseases, as well as metabolic disorders, prevent the conversion of cyanocoalamin into the active B12 forms (4) Steals methyl groups: cyanocobalamin requires a methyl group to convert into methylcobalamin, which it takes from the important amino acid S-adenosylmethionine (SAM)
Sharing needles can lead to blood-borne diseases like hepatitis or HIV
Our review provides the important potential strategies for clinical treatments
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