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Clinically, as currently the most common form of HF, HFpEF is characterized by ventricular hypertrophy and myocardial fibrosis, with signs of respiratory distress and congestion in most patients [6]

Restoring glutathione availability may lower oxidative burden, but clinical translation depends on concurrent micronutrient repletion (selenium, zinc, iron) and resolution of the primary inflammatory driver

Nausea and bloating are the most frequently reported gastrointestinal side effects of tirzepatide, but strategic dietary modifications can significantly reduce their severity and frequency

University of Washington Diabetes Institute