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Overall, compared with the large and growing amount of pre-clinical and mechanistic evidence highlighting the reward-modulating and thus potentially anti-addictive properties of GLP-1RAs, only a few studies have investigated thus far the potential use of these medications in clinical populations with alcohol- or other substance-use disorders

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GLP-1 drugs alone produced $1.1 billion dollars in claims in 2024, more than a 29% increase from 2023

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How does Retatrutide work?+ Picomolar-affinity agonist at GIP, GLP-1, and glucagon receptors

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