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Additionally, the medication affects the chemoreceptor trigger zone in your brain, a region that controls the nausea responsethis dual action explains why some patients feel queasier than others depending on their genetic sensitivity to GLP-1 signaling
These results suggested the possibility of GLP-1 as a treatment for diabetes, but limitations for therapeutic utility existed as endogenous GLP-1 had a short half-life in plasma of 1 to 2 minutes, degraded by the dipeptidyl-peptidase 4 (DPP-4) enzyme [13]
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Its also worth noting that while higher doses are linked with more frequent side effects, the severity of these symptoms can vary widely from person to person
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