gip and glp-1 pathways Gastrointestinal Incretins—Glucose-Dependent Insulinotropic Polypeptide (GIP) Glucagon-like Peptide-1 (GLP-1) beyond Pleiotropic Physiological Effects Are Involved in Pathophysiology of Atherosclerosis and Coronary Artery Disease—State of the Art Incretin-based therapies in MASLD/MASH: from

It took a month before Gammon could keep solid food down

While the efficacy of herbal GLP-1 patches is doubtful and GLP-1 drug patches are still under trial, this delivery system through skin is said to have some potential benefits like 6 : Note: The benefits mentioned above are only theoretical as there are no GLP-1 patches which are FDA approved

Survodutide is another dual GLP-1/glucagon agonist in development

1-2 servings daily, depending on activity level and climate Increase on hot days, during exercise, or if eating very little Monitor urine colorpale yellow indicates good hydration Managing Active Nausea When nausea is severe: Dilute electrolytes more than usual (1 stick in 24-32 oz water) Serve ice-cold for easier consumption Take small sips every 5-10 minutes rather than drinking full glasses Avoid citrus flavors if they worsen nauseaunflavored or mild flavors work best GLP-1 Hydration Protocol: Complete Daily Schedule Upon waking: 8-12 oz electrolyte drink (prevents morning nausea, rehydrates after overnight fast) Mid-morning: 8-12 oz plain water Before lunch: Finish first electrolyte serving if not yet complete Afternoon (2-4 PM): Second electrolyte serving if experiencing fatigue or eating very little Between meals: Plain water as tolerated Evening: Avoid large fluid volumes within 2 hours of bed (GLP-1s slow digestion, which can worsen nighttime reflux) Total daily intake goal: 64-80 oz total fluids, with 32-40 oz from electrolyte solutions Can You Drink Too Many Electrolytes on GLP-1s