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Preclinical studies in accelerated mouse models of diet-induced steatohepatitis have demonstrated that retatrutide improves steatohepatitis through mechanisms involving enhanced hepatic fat oxidation, reduced lipogenesis, decreased inflammation, and attenuation of fibrosis markers, supporting the rationale for clinical development in MASH [33]

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Is an anti-angiogenic agent targeting the VEGFR2 and CXCR4 pathways

Ozempic is primarily approved by the FDA for the treatment of type 2 diabetes to improve blood sugar control and reduce the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease [8] [9]