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Produced by osteoblasts and released into circulationparticularly in its undercarboxylated formosteocalcin has been shown in animal models to enhance insulin secretion, improve insulin sensitivity, increase energy expenditure, and stimulate testosterone production ( Mechanistically, osteocalcin signaling has been linked to the G proteincoupled receptor GPRC6A, providing a plausible pathway through which bone-derived signals influence pancreatic -cells, adipocytes, and Leydig cells
This could lead to inadequate blood glucose control, potentially causing hyperglycaemia (elevated blood sugar levels) and undermining your diabetes management
This drug has been branded as Ozempic and Wegovy
J Clin Endocrinol Metab 2002;87:12391246
