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Researchers became interested in this combination because early studies suggested that adding amylin pathway modulation to triple incretin agonism could produce synergistic effects beyond either component alone similar to how the CagriSema (cagrilintide + GLP1) combination outperformed individual components in clinical trials
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This is not just cosmeticvisceral fat is metabolically active and strongly linked to insulin resistance, fatty liver, and cardiovascular disease
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