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Xenobiotics usually trigger oxidative stress and may form electrophilic agents preferentially interacting with domains of DNA or proteins or lipids containing high electron density

Without some form of biological stratification, their average benefit across unselected patient populations may not justify these costs

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"Tirzepatide Versus Semaglutide Once Weekly as Adjunct to a Reduced-Calorie Diet and Increased Physical Activity in Adult Participants With Obesity (SURMOUNT-5)." NCT05822830