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286,287 1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) are common helper lipids in commercially available LNPs
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We believe that the GSH-regulation strategy of simultaneously depleting GSH and inhibiting GSH synthesis by BSO-based self-assembled peptide derivative would provide inspiration for the design of GSH-exhausted nanomedicines
46,47,48 In 2005, the discovery of pseudouridine () modification addressed the immunogenicity issue of in vitro-synthesized mRNA, 49 leading to the initiation of the first human trial of an mRNA vaccine against melanoma in 2008
