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363 MDM2 inhibition and wild-type p53 activation, which involves the activation of p53-targeted genes, including CDKN1A, BBC3, and Bax, and the induction of apoptosis, have beneficial effects on refractory/relapsed (R/R) AML and chronic myeloid leukemia (CML) patients
Soft Matter 18(31):5791-5806, 2022
Glucagonlike peptide1 receptor agonists (GLP1 RAs) have become key therapies in the management of obesity and type 2 diabetes, providing substantial metabolic benefits and reshaping treatment expectations
Simultaneously, there is an increase in the expression of the dopamine transporter on neuronal cells within the limbic system (LS) and striatum, leading to more efficient reuptake and reduced availability of free dopamine in these areas
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