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GHSR-1a activation in the hypothalamus triggers CRH release, which then hits anterior pituitary corticotrophs, producing ACTH and downstream cortisol elevation
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Julius D, Blair L, Brake A, Sprague G, Thorner J (1983) Yeast alpha factor is processed from a larger precursor polypeptide: the essential role of a membrane-bound dipeptidyl aminopeptidase
The selectivity profile is the standout for ipamorelin, which did not significantly raise cortisol or prolactin in the foundational animal studies
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