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PMID 14988435 Song Y, Liu J, Zhao K, Gao L, Zhao J

As shown in Figure 3F, compared to the normally polarized mitochondria (red aggregates) in control and GCMR groups, cells cultured with MET and GCMMR demonstrated huge amounts of mitochondria with abnormal depolarization (green monomer), further indicating the MET-induced inhibition on mitochondrial function

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There are counteracted muscle wasting, significantly corrected deranged muscle proliferation as well as myogenesis, counteracted increase of the proinflammatory cytokines such as IL-6 and TNF-, looking at muscle metabolism relevant to cancer cachexia as well as the changes in the expression of FoxO3a, p-AKT, p-mTOR, and P-GSK-3 (Kang et al., 2018)