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Based on current advancements in oxidative stress research in breast cancer, we propose several innovative therapeutic approaches targeting the ROSPCD network for future development: (1) Oxidative stress-directed small-molecule drugs: Natural compounds such as curcumin can induce apoptosis by triggering mitochondrial ROS bursts and DNA damage while enhancing ferroptosis sensitivity through GPX4 inhibition
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These disruptions can lead to cycles of initiation and discontinuation, reducing overall effectiveness and increasing the risk of weight regain
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Compared to tirzepatide , orforglipron offers the convenience of oral administration but may not achieve the same degree of efficacy
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