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In an insulin-resistant milieu, insulin may competitively inhibit IDE, which impedes the degradation of A proteins, increases their neurotoxicity, and contributes to the onset of AD (Scherer et al., 2021
These medications improve insulin resistance and related metabolic conditions, are increasingly used to support patients with autoimmune disease, reduce the risk of certain cardiovascular and neurologic conditions, and help manage chronic inflammation
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It also inhibits ferroptosis by lowering intracellular iron and ROS levels, increasing GPX4 expression, and reducing ACSL4
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