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Future studies expanding patient-derived brain organoids and PBMC analyses to capture genetic, immunological, and disease-stage heterogeneity, particularly during acute disease, would further improve the translational relevance and guide precision clinical trials
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However, the anabolic benefit is attenuated in the absence of adequate dietary protein IGF-1 amplifies existing recovery signals but cannot compensate for protein intake below 1.62.0 g/kg bodyweight
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