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Regular clinical review should include: Assessment of weight loss trajectory and nutritional status Evaluation of fall risk, particularly in older adults Review of concomitant medications affecting bone health Monitoring for new fractures or bone pain When to seek medical advice : Patients should contact their GP if they experience unexplained bone pain, height loss, new fractures from minimal trauma, or concerns about rapid weight loss

Yang G, Lei Y, Inoue A, Piao L, Hu L, Jiang H, Sasaki T, Wu H, Xu W, Yu C

The authors reported that AOD-9604 stimulated lipolysis in isolated adipocytes and that chronic daily treatment in obese Zucker rats produced reductions in body weight gain of more than 50% relative to untreated controls over the treatment period, without effects on insulin sensitivity or IGF-1 levels [3]

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