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Exogenous spermine significantly attenuated cardiac dysfunction in T1D rats, as characterized by improved echocardiography, decreased fibrosis, reduced myocardial ERS and oxidative stress, and increased expression of myocardial membrane CaSR
The beta-3 adrenergic receptor knockout study definitively proved the mechanism
It is for this reason we prefer the IV therapy, but may also supplement with glutathione pills
However, its always best to consult with a healthcare professional before starting any new supplement, especially if you have underlying health conditions or are taking medications
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