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Highlights: Glutathione (GSH) targets multiple hallmarks of aging, such as oxidative stress and mitochondrial dysfunction, making it a prime candidate for longevity interventions

General approach and diagnostic tools Patient history and physical examination are paramount, especially in delineating the time course and formulation of APAP ingested

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Sequence characteristics and domain organization of cysteinyl GSTs From the phylogenetic tree and the amino acid sequence alignments, there are key sequence differences that allow differentiation of each class