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For instance, tumor-associated macrophage (TAM)-derived CCL2 activates PI3K-AKT-mTOR signaling, promoting tamoxifen resistance in breast cancer via a prosurvival feedback loop
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10.1038/s41386-020-00793-7 113
Rat islet isolation and culture Islets were harvested from SpragueDawley rats (~ 250 g) that were anesthetized by an intraperitoneal injection of pentobarbital sodium (150 mg/kg)
The transcobalamin II-cobalamin (TCN2-cobalamin) complexes are taken up, from the blood, by all cells via a plasma membrane transcobalamin receptor (TCBLR) encoded by the CD320 gene
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