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All four dogs utilized were already participating in a 12-month prospective study investigating rapamycin administration, and therefore, the duration of treatment prior to pharmacokinetic analysis was variable

Unlike prior reviews, which often present descriptive overviews, this article emphasizes comparative evaluation of design principles, biological mechanisms, and translational hurdles, including biosafety, tumor heterogeneity, and large-scale manufacturability

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The regulatory situation may evolve as clinical evidence accumulates