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This dual efficacy underscores the importance of a holistic approach in treating complex metabolic diseases, where a single medication can have multiple beneficial effects

Furthermore, the homozygous ApoE4-R136S mutation (ApoE4-Ch) was shown to rescue ApoE4-driven tau pathology, neurodegeneration, and neuroinflammation in tauopathy mouse models and human iPSC-derived neurons carrying human ApoE4 with either homozygous or heterozygous R136S mutations in late-onset AD

This study documented a very modest HbA1c reduction

Concerns about the potential association between certain diabetes medications and cardiovascular disease meant that in 2010 the FDA approved liraglutide on condition that Novo Nordisk conduct a post-marketing study to evaluate the drug's effect on the incidence of major cardiovascular events (Nielsen, DeChiaro, Goldman)