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As these deeper fat compartments shrink, skin appears looser, fine lines become more noticeable, and volume diminishes in the cheeks, temples, under-eyes, and around the mouth
The anorectic and thermogenic effects of estradiol can be direct, through genomic and non-genomic mechanisms, or indirect, through activation of peripheral mediators such as cholecystokinin (CCK), insulin, leptin and GLP-1
Some patients experience nausea, constipation, diarrhea, or fatigue, especially when beginning treatment or increasing dosage
GLP-1 suppresses glucagon secretion in human pancreatic alpha cells
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