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In summary, the study demonstrates that FOXO4-DRI effectively eliminates senescent Leydig cells, improves the testicular microenvironment, and alleviates age-related testosterone secretion insufficiency, highlighting its therapeutic potential for male late-onset hypogonadism [1]

Preparation The injection site is cleaned, and a topical anesthetic may be applied to minimize discomfort

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These findings have important clinical implications, as approximately 40% of patients with the obesity phenotype of HFpEF have only mild obesity (class I), and the present analyses indicate that these patients benefit just as much as patients with more severe obesity 3