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This highlights the possibility that GLP-1 could activate VANs that innervate either the gut or the hepatoportal region to signal to the brain and back down to the pancreas via vagovagal reflexes to induce insulin secretion 124
Thursdays regulatory victory is backed by data from the Phase IIb HERIZON-BTC-01 study, which reported a 41.3% confirmed objective response rate in patients treated with Ziihera, with treatment response lasting for a median of 12.9 months
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