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Clinical trials have demonstrated that GLP-1 receptor agonists produce substantial reductions in total body weight, with emerging evidence suggesting effects on visceral adipose tissuethe metabolically active fat stored around abdominal organs
GLP-1s come with a high rate of side effects, which we will need to become skilled at avoiding and treating
The extent of loose skin depends on age, genetics, starting weight, rate of loss, and skin quality
Head-to-head clinical data from the SURMOUNT-5 trial found tirzepatide produced approximately 20% greater weight loss than semaglutide at comparable doses
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