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Patients describe a profound, unrelenting exhaustion that does not improve with rest and is dramatically worsened by physical or cognitive exertion, a pattern called post-exertional malaise (PEM)
Its prescription drug plan caps coverage of GLP-1 drugs at two years if they're used solely for weight loss
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Gene expression analysis revealed Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased 2.1-foldall statistically significant changes indicating re-entrainment of disrupted circadian oscillations
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