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In the retatrutide trials, the ratio of fat loss to lean loss was favorable compared to caloric restriction alone, where lean mass can represent 25-35% of total weight lost

Notably, the effect of tirzepatide as an anti-obesity medication is being investigated in the ongoing SURMOUNT clinical trial programme, in a similar manner to the assessment of semaglutide 2.4 mg for obesity in the Semaglutide Treatment Effect in People with obesity (STEP) programme [27]

The key differences are mentioned below

Alrededor del 40% de las personas adultas en Estados Unidos padecen obesidad, con un ndice de masa corporal (IMC) de 30 o superior