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But the greatest reduction in skin health is observed when women turn 50 years and experience menopause, which has a dramatic negative impact on skin aging owing to the loss of estrogen production from the ovaries, specifically the most potent estrogen in the body, which is 17-estradiol [2, 10, 14, 15]
This topical strategy bridges internal wellness with visible results, supporting what dermatologists now call skin longevity the idea that preserving cellular health extends not only lifespan but skinspan. The case for NAD+ NAD+ is a central metabolic coenzyme responsible for energy production, DNA repair, and the activation of longevity enzymes known as sirtuins
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