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Glutathione levels may gradually decline, and skin benefits may reduce over time.
The precise mechanism varies by treated condition, from modulating glutamate receptors in epilepsy to supporting myelin sheath formation in neuropathy
Glutathione synthetase deficiency must be distinguished from other disorders presenting as hemolytic anemia with metabolic acidosis, unexplained organic acidemia, or in older individuals with chronic progressive neurologic problems and chronic metabolic acidosis
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