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FIGURE 2 Although pharmacogenomics has advanced considerably in connecting drug responses to genetic variations, it does not account for the influence of environmental factors and the interplay between the metabolism of the individual and the gut microbiome
Lindfors et al., 2020), as well as explaining the reasons to do (or not do) investigations (e.g., colonoscopy) (Black and Ford, 2020)
In the most of the studies the primary endpoint is a change in HbA1c from baseline, except for the SURPASS J combo, where the primary endpoint is the number of patients with more than one critical adverse event (69, 70)
Herbal GLP-1 patches available in market are generally less recommended as they are not FDA approved 3
