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The competitive endogenous RNA (ceRNA) network involving circRNAs, lncRNAs, and miRNAs regulates the expression of genes involved in drug efflux, DNA repair, and apoptosis, and disruption of this network can sensitize resistant tumor cells to chemotherapy (62)
And with generic, much cheaper versions of the medications on the horizon, their use could soon grow even further
Efficacy, Tolerability and Pharmacokinetics of Combined Targeted MEK and Dual Mtorc1/2 Inhibition in a Preclinical Model of Mucosal Melanoma
Human mut-T Homologue 1 (mTH) is reported to be expressed on platelet mitochondria, and its deficiency could reduce platelet aggregation, Ca 2+ mobilization, and phosphatidyl serine exposure against thrombin exposure
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