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This guidance also describes enrichment strategiestargeted inclusion of certain populations with the goal to more readily demonstrate a drug effectand recommends that even with enrichment, trials should keep their enrollment criteria as broad and representative as possible

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Hydrophobic residues in p53 TAD2 are critical for interaction with FOXO4 FHD Based on the significance of both the TAD2 region and the C-terminus of p53 in interacting with the FOXO4 FHD, we attempted to develop an inhibitor targeting the FOXO4-p53 interaction

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