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When bound by their specific target ligand, GPCRs undergo a conformational change that facilitates recruitment and activation of a G protein through the release of GDP and subsequent exchange for a GTP
Lower risk of side effects compared to synthetic GH therapy
The balanced unimolecular tri-agonist proved superior over any existing dual co-agonists and best-in-class monoagonists to reduce body weight, enhance glycemic control and reverse non-alcoholic steatohepatitis in preclinical research [25, 27, 28]
This means that once they drive your glucose down to a fasting level, they stop
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