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The trajectory matters more than any single measurement
Underlining the translatability of findings to the human disease condition, a downregulation of the ketogenesis pathway, as expected by a drop in HMGCS2 expression, has been described for colonocytes of CD patients (35) and in line, reduced levels of the ketone body -hydroxybutyrate were observed in the colonic mucosa of IBD patients which correlated with IBD activity index (99)
This gradual approach allows gastrointestinal adaptation and improves tolerability
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