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The International Citicoline Trial on acUte Stroke (ICTUS) is a multicenter and double-blind study that assessed the effect of supplementing 2,298 patients with acute ischemic stroke with citicoline (2,000 mg/day) or a placebo for six weeks on several functional and neurologic outcomes and on mortality rate (94)

126 In the CNS, dystrophin is mainly expressed in protoplasmic astrocytes in neocortex and in velate astrocytes and Bergmann glia in the cerebellum

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However, the elevation in transcript level was found to be higher in case of thermo-tolerant genotypes (Almeselmani et al., 2013)