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You can read the abstract of this article at Type 2 diabetes is a multifaceted condition characterized by impaired insulin secretion, heightened glucagon secretion, and exacerbated insulin resistance, often linked to obesity

Wang H, Yoshizumi M, Lai KH, Tsai JC, Perrella MA, Haber E, and Lee ME (1997)

Only about 3.8% of users in clinical trials reported any side effects

Upon activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), berberine enhances insulin sensitivity, reduces hepatic glucose output, and has been shown in animal models to increase GLP-1 secretion, although this mechanism has not yet been confirmed in large human trials