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Entre estos est sitagliptina, que inhibe la degradacin de incretinas como GLP-1, lo que incrementa la secrecin de insulina, disminuye la secrecin de glucagn, retrasa el vaciamiento gstrico, reduce la ingesta de alimentos y eventualmente mejora la funcin de las clulas betas (Fig
Phase 2 clinical trials for retatrutide used a gradual titration protocol, starting at 2 mg and increasing every four weeks up to the target dose
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