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Zmijewski JW, Lorne E, Zhao X, et al
years to full benefit GHK-Cu copper peptide Direct fibroblast activation Collagen and elastin synthesis from day one Antioxidant and anti-inflammatory Well-tolerated by all skin types No increased sun sensitivity Safe for sensitive and post-procedure skin Visible improvement typically within 48 weeks The head-to-head data A 2009 split-face study published in the Journal of Cosmetic Dermatology compared a GHK-Cu cream against a retinol cream over 12 weeks
Cultures were pulse-labeled with 10 M BrdU (a nucleoside analog that competes with thymidine for incorporation into DNA) in DMEM-10% HS for the final 2-h period of 48-h in culture, followed by immunocytochemistry for detection of BrdU using G3G4 anti-BrdU mAb (1:100 dilution) and HRP-conjugated anti-mouse IgG Ab (1:500 dilution)
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