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Sociocultural factors, such as unequal access to education in the 20th century (a known protective factor), may also play a role
The endogenous ligand was finally identified in 1999 by Kojima and colleagues: ghrelin, a 28-amino-acid peptide produced mainly by the stomach
If not closely managed, this can lead to side effects such as joint pain, fluid retention, insulin resistance, and other concerns
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