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10.3390/brainsci11010027 108 ShirayamaY.KonishiT.HashimotoK
Autophagy (2014) 10(2):3823
Safety: No toxic dose has been determined to date Study in rats with a single 20mg/kg IM dose, no deaths, abnormalities in body weight, food intake, or behavior noted Study in dogs at 10mg/kg IM showed no adverse effects Study in rats of 28 days of 0.2 mg, 1mg, or 4mg/day IM no changes relative to saline injection Study in dogs of 0.1 mg, 0.5 mg, or 2 mg/day IM no changes relative to saline injection Uses: Study: protection against NSAID and alcohol adverse effects Study: healing actions on wound and injuries from trauma and systemic issues Study: benefits in neuropsychiatric conditions like depression, though other studies show it has poor penetration of the blood brain barrier
It is tempting to hypothesize that this 2:2 c-MET/HGF complex may exhibit higher activity than the 2:1 complex, due to the high structural stability
